References

[1] De, M. and Chakraborty, S.B., 2016. Use of Withania
somnifera root powder for production of monosex Nile tilapia, Oreochromis
niloticus. IOSR Journal of Pharmacy and Biological Sciences, 11(05), pp.28-31.

[2] Brownlee, K.K., Moore, A.W. and Hackney, A.C., 2005.
Relationship between circulating cortisol and testosterone: influence of
physical exercise. Journal of sports
science & medicine, 4(1),
p.76.

[3] Lopresti, A.L., Drummond, P.D. and Smith, S.J.,
2019. A randomized, double-blind, placebo-controlled, crossover study examining
the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging,
overweight males. American journal of men's health, 13(2), p.1557988319835985.

[4] Kataria, H., Gupta, M., Lakhman, S. and Kaur, G.,
2015. Withania somnifera aqueous extract facilitates the expression and release
of GnRH: in vitro and in vivo study. Neurochemistry international, 89,
pp.111-119.

[5] Dar, N.J., 2020. Neurodegenerative diseases and Withania
somnifera (L.): An update. Journal of Ethnopharmacology, p.112769.

[6] Choudhary, D., Bhattacharyya, S. and Bose, S., 2017.
Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract
in improving memory and cognitive functions. Journal of Dietary Supplements,
14(6), pp.599-612.

[7] Prakash, J., Chouhan, S., Yadav, S.K., Westfall, S.,
Rai, S.N. and Singh, S.P., 2014. Withania somnifera alleviates parkinsonian
phenotypes by inhibiting apoptotic pathways in dopaminergic neurons.
Neurochemical Research, 39(12), pp.2527-2536.

[8] Barch, D.M., 2004. Pharmacological manipulation of human
working memory. Psychopharmacology, 174(1), pp.126-135.

[9] Chandrasekhar, K., Kapoor, J. and Anishetty, S., 2012. A
prospective, randomized double-blind, placebo-controlled study of safety and
efficacy of a high-concentration full-spectrum extract of ashwagandha root in
reducing stress and anxiety in adults. Indian journal of psychological
medicine, 34(3), pp.255-262.

[10] Salve, J., Pate, S., Debnath, K. and Langade, D., 2019.
Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy
adults: a double-blind, randomized, placebo-controlled clinical study. Cureus,
11(12).

[11] Panossian, A. and Wikman, G., 2009. Evidence-based
efficacy of adaptogens in fatigue, and molecular mechanisms related to their
stress-protective activity. Current clinical pharmacology, 4(3), pp.198-219.

[12] DiNicolantonio, J.J., O’Keefe, J.H. and Wilson, W.,
2018. Subclinical magnesium deficiency: a principal driver of cardiovascular
disease and a public health crisis. Open heart, 5(1), p.e000668.

[13] Excoffon, L., Guillaume, Y.C., Woronoff-Lemsi, M.C. and
André, C., 2009. Magnesium effect on testosterone–SHBG association studied by a
novel molecular chromatography approach. Journal of pharmaceutical and
biomedical analysis, 49(2), pp.175-180.

[14] Maggio, M., De Vita, F., Lauretani, F., Nouvenne, A.,
Meschi, T., Ticinesi, A., Dominguez, L.J., Barbagallo, M., Dall’Aglio, E. and
Ceda, G.P., 2014. The interplay between magnesium and testosterone in modulating
physical function in men. International journal of endocrinology, 2014.

[15] Boomsma, D., 2008. The magic of magnesium.
International journal of pharmaceutical compounding, 12(4), pp.306-309.

[16] Held, K., Antonijevic, I.A., Künzel, H., Uhr, M.,
Wetter, T.C., Golly, I.C., Steiger, A. and Murck, H., 2002. Oral Mg2+
supplementation reverses age-related neuroendocrine and sleep EEG changes in
humans. Pharmacopsychiatry, 35(04), pp.135-143.

[17] 30. Murck H, Steiger A. Mg2+ reduces ACTH secretion and
enhances spindle power without changing delta power during sleep in
men-possible therapeutic implications. Psychopharmacology (Berl)
1998;137:247–52. [PubMed] [Google Scholar]

[18] Zhao, Z.Y. and Touitou, Y., 1993. Response of rat
pineal melatonin to calcium, magnesium, and lithium is circadian stage
dependent. Journal of pineal research, 14(2), pp.73-77.

[19] Gottesmann, C., 2002. GABA mechanisms and sleep.
Neuroscience, 111(2), pp.231-239.

[20] Pandit, S., Biswas, S., Jana, U., De, R.K., Mukhopadhyay,
S.C. and Biswas, T.K., 2016. Clinical evaluation of purified Shilajit on
testosterone levels in healthy volunteers. Andrologia, 48(5), pp.570-575.

[21] Biswas, T.K., Pandit, S., Mondal, S., Biswas, S.K.,
Jana, U., Ghosh, T., Tripathi, P.C., Debnath, P.K., Auddy, R.G. and Auddy, B.,
2010. Clinical evaluation of spermatogenic activity of processed Shilajit in
oligospermia. Andrologia, 42(1), pp.48-56.

[22] Park, J.S., Kim, G.Y. and Han, K., 2006. The
spermatogenic and ovogenic effects of chronically administered Shilajit to
rats. Journal of ethnopharmacology, 107(3), pp.349-353.

[23] Keller, J.L., Housh, T.J., Hill, E.C., Smith, C.M.,
Schmidt, R.J. and Johnson, G.O., 2019. The effects of Shilajit supplementation
on fatigue-induced decreases in muscular strength and serum hydroxyproline
levels. Journal of the International Society of Sports Nutrition, 16(1), p.3.

[24] Wessells, K.R. and Brown, K.H., 2012. Estimating the
global prevalence of zinc deficiency: results based on zinc availability in
national food supplies and the prevalence of stunting. PloS one, 7(11),
p.e50568.

[25] Prasad, A.S., Mantzoros, C.S., Beck, F.W., Hess, J.W.
and Brewer, G.J., 1996. Zinc status and serum testosterone levels of healthy
adults. Nutrition, 12(5), pp.344-348.

[26] McClain, C.J., Gavaler, J.S. and Van Thiel, D.H., 1984.
Hypogonadism in the zinc-deficient rat: localization of the functional
abnormalities. The Journal of laboratory and clinical medicine, 104(6),
pp.1007-1015.

[27] Kellokumpu, S. and Rajaniemi, H., 1981. Effect of zinc
on the uptake of human chorionic gonadotropin (hCG) in rat testis and
testosterone response in vivo. Biology of Reproduction, 24(2), pp.298-305.

[28] Om, A.S. and Chung, K.W., 1996. Dietary zinc deficiency
alters 5α-reduction and aromatization of testosterone and androgen and estrogen
receptors in rat liver. The Journal of nutrition, 126(4), pp.842-848.

[29] Ranasinghe, P., Wathurapatha, W.S., Ishara, M.H.,
Jayawardana, R., Galappatthy, P., Katulanda, P. and Constantine, G.R., 2015.
Effects of zinc supplementation on serum lipids: a systematic review and
meta-analysis. Nutrition & Metabolism, 12(1), pp.1-16.

[30] Mousavi, S.M., Mofrad, M.D., do Nascimento, I.J.B.,
Milajerdi, A., Mokhtari, T. and Esmaillzadeh, A., 2020. The effect of zinc
supplementation on blood pressure: a systematic review and dose–response
meta-analysis of randomized-controlled trials. European journal of nutrition,
59(5), pp.1815-1827.

[31] Naghii, M.R., Mofid, M., Asgari, A.R., Hedayati, M. and
Daneshpour, M.S., 2011. Comparative effects of daily and weekly boron
supplementation on plasma steroid hormones and proinflammatory cytokines.
Journal of trace elements in medicine and biology, 25(1), pp.54-58.

[32] Pizzorno, L., 2015. Nothing boring about boron.
Integrative Medicine: A Clinician's Journal, 14(4), p.35.

[33] Donoiu, I., Militaru, C., Obleagă, O., Hunter, J.M.,
Neamţu, J., Biţă, A., Scorei, I.R. and Rogoveanu, O.C., 2018. Effects of
boron-containing compounds on cardiovascular disease risk factors–a review.
Journal of Trace Elements in Medicine and Biology, 50, pp.47-56.

[34] Schulz, R. and Heusch, G., 2011. C-reactive protein:
just a biomarker of inflammation or a pathophysiological player in myocardial
function and morphology?. Hypertension, 57(2), pp.151-153.

[35] Rondanelli, M., Faliva, M.A., Peroni, G., Infantino,
V., Gasparri, C., Iannello, G., Perna, S., Riva, A., Petrangolini, G. and
Tartara, A., 2020. Pivotal role of boron supplementation on bone health: A
narrative review. Journal of Trace Elements in Medicine and Biology, 62,
p.126577.

[36] Białek, M., Czauderna, M., Krajewska, K.A. and
Przybylski, W., 2019. Selected physiological effects of boron compounds for
animals and humans. A review. Journal of Animal and Feed Sciences, 28(4),
pp.307-320.

[37] Nieschlag, E., Swerdloff, R., Behre, H.M., Gooren,
L.J., Kaufman, J.M., Legros, J.J., Lunenfeld, B., Morley, J.E., Schulman, C.,
Wang, C. and Weidner, W., 2005. Investigation, treatment and monitoring of
late-onset hypogonadism in males. The Aging Male, 8(2), pp.56-58.

[38] Tak, Y.J., Lee, J.G., Kim, Y.J., Park, N.C., Kim, S.S.,
Lee, S., Cho, B.M., Kong, E.H., Jung, D.W. and Yi, Y.H., 2015. Serum
25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean
men: a cross-sectional study. Asian Journal of Andrology, 17(2), p.324.

[39] Kumar, R., 1990. Vitamin D metabolism and mechanisms of
calcium transport. Journal of the American Society of Nephrology, 1(1),
pp.30-42.

[40] Maresz, K., 2015. Proper calcium use: vitamin K2 as a
promoter of bone and cardiovascular health. Integrative Medicine: A Clinician's
Journal, 14(1), p.34.

[41] Hariri, E., Kassis, N., Iskandar, J.P., Schurgers,
L.J., Saad, A., Abdelfattah, O., Bansal, A., Isogai, T., Harb, S.C. and
Kapadia, S., 2021. Vitamin K2—a neglected player in cardiovascular health: a
narrative review. Open heart, 8(2), p.e001715.

[42] van Summeren, M.J., Braam, L.A., Lilien, M.R.,
Schurgers, L.J., Kuis, W. and Vermeer, C., 2009. The effect of menaquinone-7
(vitamin K2) supplementation on osteocalcin carboxylation in healthy
prepubertal children. British journal of nutrition, 102(8), pp.1171-1178.

[43] Blair, H.C., Larrouture, Q.C., Li, Y., Lin, H.,
Beer-Stoltz, D., Liu, L., Tuan, R.S., Robinson, L.J., Schlesinger, P.H. and
Nelson, D.J., 2017. Osteoblast differentiation and bone matrix formation in
vivo and in vitro. Tissue Engineering Part B: Reviews, 23(3), pp.268-280.